Mangosteen supplement benefit, side effects, extract, fruit and juice information, xanthones research and the role of these substances against cancer, do these pills help prevent or treat tumors and cancers?

April 6 2014

Mangosteen is a fruit grown in Thailand and Myanmar whose rind (the pericarp) appears to have some medicinal properties. The hull of the fruit has been used for many years in Southeast Asia as a medicine for skin infection, wounds, and diarrhea, and recently other interesting properties are slowly being revealed. However, as of 2014, human trials are few regarding mangosteen juice or supplement, therefore we don't fully know its benefit in clinical practice until such studies are completed.

What's in it, what is the composition?
Mangosteen fruit has a number of compounds, the most prominent being xanthones, a group of compounds that have antioxidant and other potent physiological properties.

Benefit of mangosteen fruit, juice, or supplement
Mangosteen fruit has compounds with antioxidant, anti-bacterial, anti-fungal, and anti-tumor activity. It also appears to have anti-histamine and anti-inflammatory properties. As of 2010, almost all studies have been done in a laboratory, test tubes and cell cultures, and there is little human research to indicate how supplements or juice would influence the prevention or treatment of various cancers, including breast, lung, and liver, or what other benefits the compounds, such as xanthones, would have when ingested as a supplement. If you come across claims that it has been proven to treat cancer or to have various health benefit in humans, be skeptical. Some of these claims may eventually turn out to be true, but until actual long term human trials are done, we cannot be certain about the full benefits or side effects.
   An herbal mouthwash containing the pericarp extract may be used as an adjunct in treating bad breath.

Cancer
Laboratory testing thus far indicates that extracts of mangosteen fruit and rind, for instance the xanthones, have activity against several cancer cell lines including breast, liver, and leukemia. Other product to consider for this purpose are
Diindolemethane dim, and potent anti cancer substances in Grape Seed Extract.

Buy Mangosteen pill 500 mg capsule (whole fruit and rind) - Organic, direct from Thailand
Developed by Ray Sahelian, M.D.

Made from the highest quality ORGANIC mangosteen fruit material available, direct from Thailand. The actual active ingredients, xanthones, are mostly in the rind and seed, and less in the fruit flesh. We use the whole fruit - rind, seed and flesh - in order to provide you with the full spectrum of xanthones. There are about 20 different xanthones in the whole fruit.

Supplement Facts:
Mangosteen 500 mg each pill
   (Garcinia mangostana whole fruit, 95 percent is pericarp or rind)

 

Buy Mangosteen capsule product, acai, Goji Berry, pomegranate, noni, or hundreds of high quality products
Usage: As a dietary supplement, take one mangosteen capsule daily or as recommended by your health care provider.

Substances in the fruit and rind
Several compounds appear to be active, particularly xanthones which are unique chemical compounds found in nature, composed of a tricyclic aromatic system with a variety of phenolic, methoxy, and isoprene substituents. Some of the xanthones include mangostin, mangostenol, mangostenone A, mangostenone B, trapezifolixanthone, tovophyllin B, alpha- and beta-mangostins, garcinone B, mangostinone, and mangostanol.
   Mangosteen pericarp also has oligomeric proanthocyanidins, procyanidins, together with a few prodelphinidin units along with small amounts of stereoisomers of afzelechin, epiafzelechin, catechin, epicatechin, and gallocatechin, epigallocatechin.
   In addition to xanthones the fruit and rind have tannic acid, and polysaccharides.

Historical uses
Thailand: Treat diarrhea, dysentery, skin infections and eczema. India: Treat chronic dysentery, diarrhea, other gastrointestinal problems, gout, fevers and urinary infections. Philippines: Treat fevers, thrush, diarrhea, dysentery and urinary disorders. Malaysia: Treat stomach ache and diarrhea. China: Treat bowel complaints.

Acne vulgaris
Until human research is done, the is the only information we have on the role of mangosteen in acne inflammation.

Effect of Garcinia mangostana on inflammation caused by Propionibacterium acnes.
Fitoterapia. 2007. Mahidol University, Rachathevi, Bangkok, Thailand.
Mangosteen was highly effective in scavenging free radicals and was able to suppress the production of pro-inflammatory cytokines. This study has identified the promising source of anti-inflammatory agent which could be useful in treatment of acne vulgaris.

Alzheimer's neural damage prevention
Protective Effect of Mangosteen Extract against beta-Amyloid-Induced Cytotoxicity, Oxidative Stress and Altered Proteome in SK-N-SH Cells.
J Proteome Res. 2010. Department of Microbiology, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand, Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Institute of Biological Chemistry and Genomic Research Center, Academia Sinica, Taipei, Taiwan, Institute of Biochemical Sciences, College of Life Science, National Taiwan University, Taipei, Taiwan
Garcinia mangostana has been recognized as a major source of natural antioxidants that could decrease reactive oxygen species ROS. We examined such a protective effect of mangosteen extract by evaluating cell viability using MTT test, ROS level, caspase-3 activity, and cellular proteome. Treating SK-N-SH cells with Abeta for 24 h caused morphologically cytotoxic changes, decreased cell viability and increased ROS level, whereas preincubation with ME 30 min before the induction by Abeta successfully prevented such cytotoxic effects in a dose-dependent manner.

Antioxidant benefit and research
Antioxidant xanthones from the pericarp of Garcinia mangostana.
J Agric Food Chem. 2006. Division of Medicinal Chemistry and Pharmacognosy, The Ohio State University, Columbus, Ohio
Repeated chromatography of a CH2Cl2-soluble extract of the pericarp led to the isolation of two new highly oxygenated prenylated xanthones, 8-hydroxycudraxanthone G and mangostingone together with 12 known xanthones, cudraxanthone G, 8-deoxygartanin, garcimangosone B, garcinone D, garcinone E, gartanin, 1-isomangostin, alpha-mangostin, gamma-mangostin, mangostinone, smeathxanthone A, and tovophyllin A.

Inflammation control
Anti-inflammatory activity of mangostins from mangosteen fruit.
Food Chem Toxicol. 2007.
The mangosteen fruit hull is used as an anti-inflammatory drug in Southeast Asia. Two xanthones, alpha- and gamma-mangostins, were isolated from the fruit hull of mangosteen, and both significantly inhibited nitric oxide (NO) and PGE(2) production from lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Alpha- and gamma-mangostins from mangosteen fruit are bioactive substances with anti-inflammatory effects.

Heart health
Cardioprotective effect of alpha-mangostin, a xanthone derivative from mangosteen on tissue defense system against isoproterenol-induced myocardial infarction in rats.
J Biochem Mol Toxicol. 2007. Centre for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai, India.
The present study was designed to evaluate the effect of alpha-mangostin on the antioxidant defense system and lipid peroxidation against isoproterenol-induced myocardial infarction in rats. Our findings indicate the protective effect of mangosteen extract alpha-mangostin on lipid peroxidation and antioxidant tissue defense system during isoproterenol-induced myocardial infarction in rats.

Platelet number
Will a mangosteen supplement increase my platelet count. I am at 30,000.
   A low platelet count can be due to many causes. Human research is lacking, therefore it is difficult to say what influence it has on platelets.

Benefit of mangosteen fruit versus the rind
Most of the studies have focused on the pericarp, or the dark, woody rind as opposed to the fruit inside the woody rind. The pericarp contains most of the active xanthone compounds. The fruit itself probably has some beneficial compounds but the compounds within the fruit have not been studied as well as the rind.

Mangosteen fruit, juice, and supplement recommendations, review
Until human trials are done, it is difficult to make any recommendations regarding its health benefit. Does it work well when taken as a supplement? What is the ideal dosage? How often should capsules be taken and for how long? Does mangosteen have side effects when taken for several months or years? These are questions that still need to be answered through rigorous research.  However, some of the in vitro studies regarding its anti-cancer potential are intriguing and certainly worthwhile to further explore. Several compounds found in the fruit may have potential health benefits in humans. However, until actual research human studies are done, it is difficult to know for certain what role mangosteen juice or supplements play in health and disease.

Mangosteen side effects, safety, caution
We have taken four mangosteen capsules daily for one week and did not experience any side effects. Adverse reactions to use of mangosteen pills for several months or years is not known. For this reason, we suggest you take a few days off each month.

For dogs
Please advise what the proper mangosteen dosage would be for a 12 yr old Golden Retriever. Our dog was put on Deramaxx by the Veterinarian, but is having side effects I do not like Deramaxx and I will discontinue those pills. Our dog exhibited signs of osteoarthritis, having difficulty getting up and down and climbing stairs, and was stiff and seemed to be in pain.
   We have not seen any studies with the use of mangosteen for dogs or other animals in terms of arthritis treatment. It is a safe herb and one or two capsules appear not to give side effects in humans, but we can't predict what it would do in a dog when used for prolonged periods.

Combining with other nutraceuticals
Are there any problems taking a mangosteen pill along with an acai berry pill?
   Probably not if you take one pill of each. But first, familiarize yourself on how you react to each one separately makes you feel before combining. Both have mild influences on the body, they don't stimulate the body too much and they appear to be safe. Take a few days off each month.

Can mangosteen pills be taken the same day as Asparagus Extract pills?
    Probably, but we have not seen such specific research trials.

Testimonial
Two years ago, I was so weak, that I could hardly get out of bed. I have peripheral neuropathy, chronic fatigue and fibromyalgia, as well as a non-reparable ruptured spine. After taking mangosteen supplement for a month, I was out doing things in the kitchen for about 10 or 15 minutes at a time. Due to the pain in my feet and back, I can not stand very long, but I had a new energy that helped me get up and around. Mangosteen gave me so much more energy, that after a month, even my husband noticed and said this new stuff must be helping you. The doctors could find no medications to help me feel better, and I can only take narcotic pain pills to keep the pain down. I think the dark reddish brown capsules are wonderful. was sweet. I thought it would make a good tea, but I've been reading that it is non-soluble, so that would not work. I would not buy the juice. It is diluted with pear and apple juice, and costs much too much money for me. Thanks for your response. I'm happy to hear your capsules are the reddish brown.

Mangosteen saved my life against a bacterium from space. My infectious disease md tried all that he had to kill a bacterium from space imbedded in a spinal device made to keep my cervical spine attached from an injury. The bacterium has eaten a portion of my back before I found your Mangosteen. My doctor now uses it in cases such as mine. I have had a total of 10 spinal operations over a 20 year period and have become allergic to any opiates and pain meds are out of my life. During two of the ten I had to be alert during the surgeries. Wide awake and no pain or numbing meds. Try this once. At the now age of 71, my pain is really getting to me. One of the operations has failed and I must live with this.

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To see a video on You Tube regarding the benefits and adverse reactions, see Youtube Mangostten pill supplement